Accelerated ADC Drug Discovery Searchlight Journal Club

Clinical Successes and Failures in ADCs

Thursday June 22nd | 11:00am - 12:30pm EST | Digital

The Accelerated ADC Drug Discovery Searchlight network launches its new Journal Club, where the network members delve into the latest research and advancements in the field. In this edition, the network will be focusing on Clinical Successes and Failures in ADCs.

To achieve a more focused discussion, this meeting will be split into two halves: the first led by Deya Gonzalez, Professor of Molecular Medicine at Swansea University, delving into discontinued ADCs and showcasing a case study from Beacon Intelligence by Hanson Wade.

In 2022, 6% of ADCs were discontinued, 4% clinically inactive and 22% pre-clinically inactive. Reasons for this can include challenges like having the wrong target, payload or linker. Frustratingly, very little on this gets published, meaning that we can't learn from previous failures or look to them for insight into what didn’t work. Journal club wants to wants to change this.

In the second half of the meeting, Sonia Jain, Principal Researcher at the Mayo Clinic will present data focusing on challenging ADCs, where one target may be presented with different payloads providing opportunities for valuable discussion around target and payload pairing combinations.

What Will Participants Learn?

The goal of the Journal Club is for participants to leave having gained valuable insights and learnings from the successes and failures of previous ADCs. Through the analysis of the data and case studies presented, members will walk away with strategies on how to streamline the development of ADCs, gain deeper insights on what a perfect pair of targets and payloads looks like and gain a deeper understanding of pairings, targets with payload pairings and data combinations within ADCs.

We have a limited number of places available for the Accelerated ADC Drug Discovery Journal Club, so if you would value the opportunity to join, apply by completing the form.

An Opportunity to Engage with ADC Leaders from the likes of: